Percorrer por autor "Dias, Juliana Rosa"
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- Expanding the Potential of Self-Assembled Silk Fibroin as Aerogel Particles for Tissue RegenerationPublication . Bernardes, Beatriz G.; Baptista-Silva, Sara; Illanes-Bordomás, Carlos; Magalhães, Rui; Dias, Juliana Rosa; Alves, Nuno M. F.; Costa, Raquel; García-González, Carlos A.; Oliveira, Ana LeiteA newly produced silk fibroin (SF) aerogel particulate system using a supercritical carbon dioxide (scCO2)-assisted drying technology is herein proposed for biomedical applications. Different concentrations of silk fibroin (3%, 5%, and 7% (w/v)) were explored to investigate the potential of this technology to produce size- and porosity-controlled particles. Laser diffraction, helium pycnometry, nitrogen adsorption–desorption analysis and Fourier Transform Infrared with Attenuated Total Reflectance (FTIR-ATR) spectroscopy were performed to characterize the physicochemical properties of the material. The enzymatic degradation profile of the SF aerogel particles was evaluated by immersion in protease XIV solution, and the biological properties by cell viability and cell proliferation assays. The obtained aerogel particles were mesoporous with high and concentration dependent specific surface area (203–326 m2/g). They displayed significant antioxidant activity and sustained degradation in the presence of protease XIV enzyme. The in vitro assessment using human dermal fibroblasts (HDF) confirm the particles’ biocompatibility, as well as the enhancement in cell viability and proliferation.
- Manufacturing a Better Future: Scientific Report 2018-2023Publication . Ruben, Rui Miguel Barreiros; Gaspar, Marcelo Rudolfo Calvete; Dias, Juliana Rosa; Ruben, Rui; Calvete Gaspar, Marcelo; Dias, Juliana; Politécnico de LeiriaThe Centre for Rapid and Sustainable Product Development (CDRSP) of the Polytechnic of Leiria (IPL) is a leading research center with the mission of contributing to scientific and technological development through new products, materials and processes that are more sustainable, effective, and efficient. The CDRSP is an organic research unit of the IPL. It was founded in May 2007 to promote economic competitiveness, social cohesion, and sustainable development through new, more efficient, and sustainable products, materials, and processes. Portuguese Additive Manufacturing Initiative (PAMI) was a project that finished in 2021 and CDRSP was the leader. PAMI was a network for fundamental research and development of new techniques for additive manufacturing. The PAMI network was part of the National Roadmap of Research Infrastructures of Strategic Interest to foster an intelligent distribution of the excellent infrastructures that already exist in the central region of Portugal, with different areas of specialty (mechanics, materials, biomedical, and electronics) to increase competitiveness and the capacity to fix the high-performance production sector.