CDRsp - Comunicações em conferências internacionais
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- Adhesion, proliferation and distribution of human mesenchymal stem/stromal cells (MSCs) in Poly(ɛ -caprolactone) (PCL) scaffolds with different pore sizesPublication . Moura, C. S.; Biscaia, S.; Viana, T.; Bártolo, P. J.; Silva, C. L. da; Cabral, J. S.; Ferreira, F. C.Tissue engineering, combining the use of biomaterials, mesenchymal stem/stromal cells (MSCs) and optimized culture medium formulations, is a very promising research field for tissue regeneration. This work is focused on the application of Poly(ε-caprolactone) scaffolds designed to have a spacing gradient between orthogonal fibres with diameters of 0.3mm with pore sizes ranging from 190 to 390 μm. Human bone marrow (BM)-derived MSCs, were used to evaluate cell adhesion, proliferation and distribution within the scaffolds. Specifically, we hypothesized if seeding MSC in scaffold regions with different pore sizes would influence cell proliferation. Therefore, MSC were seeded at the centre of scaffolds with either larger (390 μm) or smaller pores (190 μm). Results obtained showed similar levels of adhesion and proliferation in both configurations, with fold increase in total cell number of 5 after 13 days of cultivation; which indicates that no limitation for cell proliferation within the range of pore sizes studied is observed.
- BioFab toolbox – Software tools for biofabricationPublication . Alves, N.; Bártolo, P.; Ferreira, N.; Gaspar, M.; Mateus, A.This is a progress report of a project called BioFab Toolbox, funded by the Portuguese National Science Foundation, consisting of the development of a collection of software tools to assist in the process of rapid prototyping and rapid manufacturing of new products. This project is especially designed to produce scaffolds, grafts, implants and other medical applications usually designated as biofabrication (biofab).
- Direct writing of conductive polymer tracks as part of an additive manufacturing processPublication . Mitchell, G. R.; Davis, Fred J.The use of electrically conductive polymers to construct hetereogenous structures via additive manufacturing is an attractive possibility. It maintains the all polymeric nature of such structures. In this work we discuss how this might be achieved in practical additive manufacturing equipment.
- Feasibility Study of the PET Fines Incorporation into Recycling ProcessesPublication . Nascimento, Bruna Guilherme do; Bozzola, Fernando; Vasco, Joel C.; Parnigoni, Milena; Capela, Carlos; Heleno, Lizete; Gaspar, Marcelo; Oliveira, Nelson S.Circular economy principles focus on the need to preserve natural resources and foster the use of environmentally sustainable practices. Concerning the use of plastics in a circular economy, increasingly demanding solutions have to be developed towards the zero-waste goal sought after by researchers and society alike. Particular attention has been put into the recycling of PET, mainly due to its wide spectrum of use and, consequently, to large volumes of related waste. The PET mechanical recycling process requires these waste materials to be shredded into PET flakes. Following such a procedure, these flakes are pelletized to be used again as feedstock. Considering the main stages of the mechanical recycling processes, which include plastic screening, shredding and washing, significant amounts of end waste materials are generated. This end-waste integrates small scale particles that are designated by plastic fines. Concerning the PET recycling process, the PET fines resulting from its mechanical recycling are not currently valued due to several technical issues, such as their high contamination level and the complexity of sorting them from other small-size particles. Current research focuses on the feasibility of incorporating these PET fines into the film/injection extruders, avoiding this way the need for an intermediate pelletization stage. To allow for such direct incorporation of PET fines into recycling processes, different decontamination and sorting solutions were implemented and tested. The current study is based on analyzing the mechanical properties of PET fines, using laboratory tests such as FTIR, DSC, MFI, moisture content, tensile tests and bending tests. Preliminary results allow foreseeing the successful direct incorporation of PET fines into PET recycling.
- Further remarks on the "Smith is Huq" conditionPublication . Martins-Ferreira, Nelson; Van der Linden, TimWe compare the Smith is Huq condition (SH) with three commutator conditions in semi-abelian categories: first an apparently weaker condition which arose in joint work with Bourn and turns out to be equivalent with (SH), then an apparently equivalent condition which takes commutation of non-normal subobjects into account and turns out to be stronger than (SH). This leads to the even stronger condition that weighted commutators in the sense of Gran, Janelidze and Ursini are independent of the chosen weight, which is known to be false for groups but turns out to be true in any two-nilpotent semi-abelian category.
- Ink Removal on Plastic Films Printed by FlexographyPublication . Bozzola, Fernando; Nascimento, Bruna Guilherme do; Vasco, Joel C.; Silva, Nelson; Lagoa, Fernando; Capela, Carlos; Heleno, Lizete; Gaspar, Marcelo; Oliveira, Nelson S.Plastics are key engineering materials for our society and economy, mainly due to their multifunctionality and ease of processing. Nonetheless, their main drawback is related to the fact that when these cannot be reprocessed, they do generate waste, which leads to several environmental impacts. Therefore, considering plastics’ circularity, minimizing their waste, and the resulting impacts, stresses the need for these to be recyclable. One of the main challenges that concern their recyclability is the deinking of plastic films when printed by flexography. The current technology uses non-bio-based surfactants and non-renewable surfactants, which are harmful to the environment. Therefore, the main objective of current research is to develop an environmentally sustainable process for ink removal on printed post-industrial flexible plastic films using bio-based surfactants. This process focuses on obtaining a deinked plastic that may be reprinted, avoiding this way for inappropriate disposal or reprocessing problems. The value increase of upcycling such post-industrial waste makes it possible to match the quality of the virgin plastic, which is key to carrying out an effective cost analysis of recycled plastic when compared to the new plastic films. Dedicated laboratory deinking procedures were undertaken with transparent polyethylene films printed by flexography with different conditions. Preliminary results show the dedicated experimental ink removal procedure using bio-based surfactants to be effective and environmentally sustainable.
- Innovative developments on Agile-CAD systemPublication . Gaspar, M.; Alves, N.; Martins-Ferreira, N.; Bártolo, P.Agile-CAD is a reverse engineering computer tool that allows the recovering of outer and inner 3D shapes of existing objects of revolution with constant thickness, using silhouettes computed from one or two digital views. In this context, some improved algorithms were developed in order to provide more accurate and robust tridimensional reconstruction when using a single digital image as source. Experimental results based on real images are presented, demonstrating the good performance of this computer tool.
- Materials characterization for stereolithographyPublication . Camaño, Patricia; Bartolo, Paulo J.Stereolithography is an additive technology that allows the fabrication of three-dimensional macro and micro-parts for industrial and medical applications. By solidifying a liquid photo-sensitive monomer with a laser or UV-light source a polymeric part is built up layer by layer. The use of highly reinforced polymeric systems with metallic or ceramic particles also enables to transform this rapid prototyping technology into a rapid manufacturing one. The quality and fabrication speed of stereolithographic parts strongly depends on the curing kinetics. Therefore it is crucial to optimize the polymeric mixture for a specific application. This research work investigates the curing kinetics of reinforced and non-reinforced unsaturated polyester resins with different photo-initiator concentrations. Two types of particles were considered: tungsten carbide and hydroxyapatite (concentrations of 30 wt%).
- Structure development during additive manufacturingPublication . Tojeira, A.; Biscaia, S.; Viana, T.; Bártolo, P. J.; Mitchell, G. R.Additive manufacturing involves the shaping of a product through the use of a liquid phase which is subsequently transformed to the solid state by cooling or through the use of chemical cross-linking reactions. Of particular note is the fused deposition modeling which utilizes semi-crystalline polymers such as poly(ε-caprolactone) or poly(lactic acid) and has been employed in CDRsp to prepare highly porous scaffolds for Tissue Engineering. We show that the crystallization process amplifies small levels of molecular anisotropy introduced in the additive writing process. We show that the level of anisotropy is significantly dependent on the process parameters such as temperature, write speed, and flow rate. The differences in the crystalline morphology introduced by changing these process parameters will have a marked impact on the mechanical properties. This in turn will alter the growth of tissue on such scaffold structures. As with other polymer processing procedures, tuning the process parameters provides a route to controlling and defining the structure and morphology of the scaffold and the properties exhibited by that scaffold.
- Thermal analysis of an extrusion system of a 3-D bioprinterPublication . Ribeiro G.S.; Silva J.V.L.; Freitas D.; Bartolo P.; Almeida, Henrique de Amorim; Silveira Z.C.This work presents a finite element thermal analysis of a 3-D bioprinter desktop based on Fused Deposition Modeling (FDM) with applications on tissue engineering, designed by the Centre for Rapid and Sustainable Product Development - Leiria, Portugal. The purpose of this work it is compare three possibilities of temperature control of the machine during the extrusion process, considering the use of a biodegradable polyester (Polycaprolactone - PCL) as raw material. The first two configurations simulate approaches typically adopted in an attempt to keep the polymer as close as possible to 80 °C and prevent its premature solidification at a critical point. The third configuration considers a hypothetical material substitution to enhance thermal conductivity. The results indicate that the first two configurations are not sufficient to achieve total control of the polymer temperature. However, the third configuration show a significant potential to improve the thermal control of the extrusion process.