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An introduction to scaffold design using topology optimization methods
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| In this text, the fundamentals of topology optimization (TO) are applied to trabecular bone's topology design, with the goal of then extrapolating their uses to bio-scaffold design for regenerative therapy. Total fragility bone fractures in the EU are estimated to increase from 2.7 million in 2017 to 3.3 million in 2030; a 23% increase. The resulting annual fracture-related costs (€37.5 billion in 2017) are expected to increase by 27%. An estimated 1.0 million quality-adjusted life years were lost in 2017 due to fragility fractures. The current disability-adjusted life years per 1000 individuals age 50 years or more were estimated at 21 years, which is higher than the estimates for stroke or chronic obstructive pulmonary disease (see [1]). Healing of bone fractures and reconstruction of critical-sized bone defects represent a significant challenge. With bone graft and synthetic material reconstruction techniques having their unfortunate limitations, bio-scaffolds came into play to get the best of both. Since scaffolds require very high porosity levels for osteoconductivity and must simultaneously bear a great amount of force occurring from the daily loads a patient experiences, structural analysis is indispensable to optimize their mechanical properties. Also, materials used for scaffold design are not as nearly as stiff as native bone, making optimization even more crucial. The Solid Isotropic Material with Penalization (SIMP) method for TO is quickly discussed and a perimeter constraint is introduced to impose porous-like structures in the design. Then, a topology optimization analysis is performed to mimic the trabecular architecture of a human's proximal femur. The femur's boundary conditions when it's subjected to daily gait are talked through. Lastly, an application to scaffold design is discussed. | 806.73 KB | Adobe PDF |
Orientador(es)
Resumo(s)
In this text, the fundamentals of topology optimization (TO) are applied to trabecular bone's topology design, with the goal of then extrapolating their uses to bio-scaffold design for regenerative therapy. Total fragility bone fractures in the EU are estimated to increase from 2.7 million in 2017 to 3.3 million in 2030; a 23% increase. The resulting annual fracture-related costs (€37.5 billion in 2017) are expected to increase by 27%. An estimated 1.0 million quality-adjusted life years were lost in 2017 due to fragility fractures. The current disability-adjusted life years per 1000 individuals age 50 years or more were estimated at 21 years, which is higher than the estimates for stroke or chronic obstructive pulmonary disease (see [1]). Healing of bone fractures and reconstruction of critical-sized bone defects represent a significant challenge. With bone graft and synthetic material reconstruction techniques having their unfortunate limitations, bio-scaffolds came into play to get the best of both. Since scaffolds require very high porosity levels for osteoconductivity and must simultaneously bear a great amount of force occurring from the daily loads a patient experiences, structural analysis is indispensable to optimize their mechanical properties. Also, materials used for scaffold design are not as nearly as stiff as native bone, making optimization even more crucial. The Solid Isotropic Material with Penalization (SIMP) method for TO is quickly discussed and a perimeter constraint is introduced to impose porous-like structures in the design. Then, a topology optimization analysis is performed to mimic the trabecular architecture of a human's proximal femur. The femur's boundary conditions when it's subjected to daily gait are talked through. Lastly, an application to scaffold design is discussed.
Descrição
Conference name - International Conference on Numerical Analysis and Applied Mathematics 2021, ICNAAM 2021; Conference date -
20 September 2021 - 26 September 2021; Conference code - 192641
Link para o documento - https://www.researchgate.net/publication/373605625_An_introduction_to_scaffold_design_using_topology_optimization_methods
Link para o documento - https://www.researchgate.net/publication/373605625_An_introduction_to_scaffold_design_using_topology_optimization_methods
Palavras-chave
Porous media Mathematical optimization Trabecular bone Femur
Contexto Educativo
Citação
Jan Esquível Marxen, T. Charters, Sérgio Lopes, N. D. Lopes, Nuno Manuel Fernandes Alves, Paula Pascoal-Faria; An introduction to scaffold design using topology optimization methods. AIP Conf. Proc. 1 September 2023; 2849 (1): 150002. https://doi.org/10.1063/5.0162364.
Editora
AIP
Licença CC
Sem licença CC