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Editorial: Aquaculture of emergent marine invertebrates: Advances in nutrition, rearing technology and end-product quality

2022-12-22Editorial de revista Acesso aberto
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datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.sdg14:Proteger a Vida Marinha
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorLourenço, Sílvia
dc.contributor.authorValente, Luísa M. P.
dc.date.accessioned2026-10-07T17:55:10Z
dc.date.available2026-10-07T17:55:10Z
dc.date.issued2022-12-22
dc.descriptionArticle number - 1119422.
dc.descriptionAcknowledgments: SL acknowledges Fundação para a Ciência e Tecnologia (FCT), through the strategic project LA/P/0069/2020 granted to the Associate Laboratory ARNET and UIDB/04292/2020 and UIDP/04292/2020 awarded to the MARE-Marine and Environmental Sciences Centre.
dc.description.abstractPolyphenols exhibit a wide range of biological and pharmacological activities, yet their dermal delivery is often limited by skin permeability and formulation-dependent constraints. In this work, the potential of roller microneedling as a physical strategy to improve dermal delivery of representative polyphenols—epicatechin, epigallocatechin gallate (EGCG), and curcumin—was investigated using common topical dosage forms, namely polymeric gel, patch, and ointment. Standardized skin permeation parameters were first obtained using excised porcine skin under conditions of stratum corneum saturation. The microneedling procedure was characterized, and its effect on polyphenol transdermal permeation from each formulation type was evaluated using Franz diffusion cells. Maximum steady-state permeation fluxes varied from 13.2 μg/cm2/h (curcumin) to 708 μg/cm2/h (epicatechin). Roller microneedling produced well-defined microchannels across the stratum corneum, with a mean interchannel distance of 2.3 mm, without compromising skin integrity, and significantly enhanced polyphenol permeation from all tested vehicles. Depending on the compound and formulation, microneedling increased permeation fluxes and/or reduced lag times, with particularly relevant effects observed for gel-delivered curcumin and ointment-delivered EGCG. Moreover, the polyphenols exhibited a robust antioxidant activity (equivalent to micromolar ascorbic acid) after transdermal permeation, including following microneedle-assisted delivery, supporting the compatibility of microneedling and the formulation vehicles with polyphenol functionality. Overall enhancement factors were consistent, yielding approximately twofold increases in both permeation flux and antioxidant activity. These findings demonstrate that roller microneedling is a practical, low-invasive approach to enhance the dermal delivery of polyphenols from conventional topical formulations, offering a versatile strategy that complements formulation-based optimization for therapeutic and cosmetic applications.eng
dc.description.sponsorshipFundação para a Ciência e Tecnologia (FCT), through the strategic project LA/P/0069/2020 granted to the Associate Laboratory ARNET and UIDB/04292/2020 and UIDP/04292/2020 awarded to the MARE-Marine and Environmental Sciences Centre.
dc.identifier.citationLourenço, S., & Valente, L. M. P. (2022). Editorial: Aquaculture of emergent marine invertebrates: Advances in nutrition, rearing technology and end-product quality. Frontiers in Marine Science, 9, Artigo 1119422. https://doi.org/10.3389/fmars.2022.1119422
dc.identifier.doi10.3389/fmars.2022.1119422
dc.identifier.issn2296-7745
dc.identifier.urihttp://hdl.handle.net/10400.8/16991
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media SA
dc.relationAquatic Research Infrastructure Network
dc.relationMarine and Environmental Sciences Centre
dc.relationMarine and Environmental Sciences Centre
dc.relation.hasversionhttps://www.frontiersin.org/journals/marine-science/articles/10.3389/fmars.2022.1119422/full
dc.relation.ispartofFrontiers in Marine Science
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAlginate
dc.subjectCurcuminoids
dc.subjectDrug delivery
dc.subjectFlavonoids
dc.subjectMedical devices
dc.subjectPluronic F-127
dc.titleEditorial: Aquaculture of emergent marine invertebrates: Advances in nutrition, rearing technology and end-product qualityeng
dc.typeeditorial
dspace.entity.typePublication
oaire.awardNumberLA/P/0069/2020
oaire.awardNumberUIDB/04292/2020
oaire.awardNumberUIDP/04292/2020
oaire.awardTitleAquatic Research Infrastructure Network
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0069%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04292%2F2020/PT
oaire.citation.endPage3
oaire.citation.startPage1
oaire.citation.titleFrontiers in Marine Science
oaire.citation.volume9
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNamePereira Lourenço
person.givenNameSílvia Alexandra
person.identifier.ciencia-id1E12-4289-7CF3
person.identifier.orcid0000-0003-4426-0894
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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