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Are There Lipid Membrane-Domain Subtypes in Neurons with Different Roles in Calcium Signaling?

2023-12-02Artigo científico Acesso aberto
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datacite.subject.fosCiências Naturais::Ciências Químicas
datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.fosCiências Médicas::Outras Ciências Médicas
datacite.subject.sdg11:Cidades e Comunidades Sustentáveis
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorSamhan-Arias, Alejandro K.
dc.contributor.authorPoejo, Joana
dc.contributor.authorMarques-da-Silva, Dorinda
dc.contributor.authorMartínez-Costa, Oscar H.
dc.contributor.authorGutierrez-Merino, Carlos
dc.date.accessioned2026-10-07T10:03:58Z
dc.date.available2026-10-07T10:03:58Z
dc.date.issued2023-12-02
dc.description.abstractLipid membrane nanodomains or lipid rafts are 10–200 nm diameter size cholesterol- and sphingolipid-enriched domains of the plasma membrane, gathering many proteins with different roles. Isolation and characterization of plasma membrane proteins by differential centrifugation and proteomic studies have revealed a remarkable diversity of proteins in these domains. The limited size of the lipid membrane nanodomain challenges the simple possibility that all of them can coexist within the same lipid membrane domain. As caveolin-1, flotillin isoforms and gangliosides are currently used as neuronal lipid membrane nanodomain markers, we first analyzed the structural features of these components forming nanodomains at the plasma membrane since they are relevant for building supramolecular complexes constituted by these molecular signatures. Among the proteins associated with neuronal lipid membrane nanodomains, there are a large number of proteins that play major roles in calcium signaling, such as ionotropic and metabotropic receptors for neurotransmitters, calcium channels, and calcium pumps. This review highlights a large variation between the calcium signaling proteins that have been reported to be associated with isolated caveolin-1 and flotillin-lipid membrane nanodomains. Since these calcium signaling proteins are scattered in different locations of the neuronal plasma membrane, i.e., in presynapses, postsynapses, axonal or dendritic trees, or in the neuronal soma, our analysis suggests that different lipid membrane-domain subtypes should exist in neurons. Furthermore, we conclude that classification of lipid membrane domains by their content in calcium signaling proteins sheds light on the roles of these domains for neuronal activities that are dependent upon the intracellular calcium concentration. Some examples described in this review include the synaptic and metabolic activity, secretion of neurotransmitters and neuromodulators, neuronal excitability (long-term potentiation and long-term depression), axonal and dendritic growth but also neuronal cell survival and death.eng
dc.description.sponsorshipWe would like to thank Molecules and MDPI for the support and organization of the Special Issue dedicated to Carlos Gutiérrez-Merino: “Themed Issue in Honor of Carlos Gutiérrez Merino: Forty Years of Research Excellence in the Field of Membrane Proteins and Bioenergetics.”.
dc.identifier.citationSamhan-Arias, A.K.; Poejo, J.; Marques-da-Silva, D.; Martínez-Costa, O.H.; Gutierrez-Merino, C. Are There Lipid Membrane-Domain Subtypes in Neurons with Different Roles in Calcium Signaling? Molecules 2023, 28, 7909. https://doi.org/10.3390/molecules28237909.
dc.identifier.doi10.3390/molecules28237909
dc.identifier.eissn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.8/16981
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.hasversionhttps://www.mdpi.com/1420-3049/28/23/7909
dc.relation.ispartofMolecules
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectflotillin
dc.subjectcaveolin
dc.subjectganglioside
dc.subjectlipid rafts
dc.subjectlipid membrane domains
dc.subjectcalcium channel
dc.subjectNMDA
dc.subjectPMCA
dc.subjectP2XR
dc.subjectmembrane domains
dc.subjectneuron
dc.subjectbrain
dc.titleAre There Lipid Membrane-Domain Subtypes in Neurons with Different Roles in Calcium Signaling?eng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage34
oaire.citation.issue23
oaire.citation.startPage1
oaire.citation.titleMolecules
oaire.citation.volume28
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMarques da Silva
person.givenNameDorinda
person.identifier.ciencia-id521A-35C1-078D
person.identifier.orcid0000-0003-0460-5421
relation.isAuthorOfPublication475787c4-cf46-4b3b-96ec-a5278d5cc6f5
relation.isAuthorOfPublication.latestForDiscovery475787c4-cf46-4b3b-96ec-a5278d5cc6f5

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Lipid membrane nanodomains or lipid rafts are 10–200 nm diameter size cholesterol- and sphingolipid-enriched domains of the plasma membrane, gathering many proteins with different roles. Isolation and characterization of plasma membrane proteins by differential centrifugation and proteomic studies have revealed a remarkable diversity of proteins in these domains. The limited size of the lipid membrane nanodomain challenges the simple possibility that all of them can coexist within the same lipid membrane domain. As caveolin-1, flotillin isoforms and gangliosides are currently used as neuronal lipid membrane nanodomain markers, we first analyzed the structural features of these components forming nanodomains at the plasma membrane since they are relevant for building supramolecular complexes constituted by these molecular signatures. Among the proteins associated with neuronal lipid membrane nanodomains, there are a large number of proteins that play major roles in calcium signaling, such as ionotropic and metabotropic receptors for neurotransmitters, calcium channels, and calcium pumps. This review highlights a large variation between the calcium signaling proteins that have been reported to be associated with isolated caveolin-1 and flotillin-lipid membrane nanodomains. Since these calcium signaling proteins are scattered in different locations of the neuronal plasma membrane, i.e., in presynapses, postsynapses, axonal or dendritic trees, or in the neuronal soma, our analysis suggests that different lipid membrane-domain subtypes should exist in neurons. Furthermore, we conclude that classification of lipid membrane domains by their content in calcium signaling proteins sheds light on the roles of these domains for neuronal activities that are dependent upon the intracellular calcium concentration. Some examples described in this review include the synaptic and metabolic activity, secretion of neurotransmitters and neuromodulators, neuronal excitability (long-term potentiation and long-term depression), axonal and dendritic growth but also neuronal cell survival and death.
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LSRE-LCM - Artigos em Revistas Nacionais e de Circulação Internacional
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