The influence of scaffold design in electrical field distribution for tissue engineering

Meneses, João; Moura, Carla; Datta, Abhishek; Amado, Sandra; Alves, Nuno; Pascoal-Faria, Paula

http://hdl.handle.net/10400.8/17126

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The Influence of Scaffold Design in Electrical Field Distribution for Tissue Engineering.pdf	Regarding electric field stimulation in tissue engineering, namely in bone in vitro stimulation, we wonder if by introducing different scaffold geometries into the cell culture chamber environment, we are changing the externally applied electric field magnitude. Also, if we assume that the presence of the scaffold changes the magnitude of the surrounding electric field, can we just by picking a specific scaffold material be delivering electric fields outside the osteoinductive range for that specific cell line. To answer these questions, numerical models for three different scaffold geometries and for a capacitively coupled system were created. The models allow to understand that the presence of the scaffold impacts and interferes with its surrounding electric field, generating patterns that may increase the electric field magnitude in some regions inside the scaffod, and at the same time may block the electric field in other regions of the same scaffold. Another insigth from numerical models is that even keeping the same scaffold geometry, just by changing the scaffold material we are changing this interference pattern and delivering different electric fields in the scaffold region-of-interest.	1.15 MB	Adobe PDF	Ver/Abrir

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Resumo(s)

Regarding electric field stimulation in tissue engineering, namely in bone in vitro stimulation, we wonder if by introducing different scaffold geometries into the cell culture chamber environment, we are changing the externally applied electric field magnitude. Also, if we assume that the presence of the scaffold changes the magnitude of the surrounding electric field, can we just by picking a specific scaffold material be delivering electric fields outside the osteoinductive range for that specific cell line. To answer these questions, numerical models for three different scaffold geometries and for a capacitively coupled system were created. The models allow to understand that the presence of the scaffold impacts and interferes with its surrounding electric field, generating patterns that may increase the electric field magnitude in some regions inside the scaffod, and at the same time may block the electric field in other regions of the same scaffold. Another insigth from numerical models is that even keeping the same scaffold geometry, just by changing the scaffold material we are changing this interference pattern and delivering different electric fields in the scaffold region-of-interest.

Descrição

Conference name - International Conference on Numerical Analysis and Applied Mathematics 2021, ICNAAM 2021; Conference date - 20 September 2021 - 26 September 2021; Conference code - 192641
Link para o documento - https://www.scilit.com/publications/fe264569a4064f7b90ad4b49bab117b1

Palavras-chave

Numerical methods Tissue engineering Cell cultures Cell lines

URI

http://hdl.handle.net/10400.8/17126

Citação

João Meneses, Carla Moura, Abhishek Datta, Sandra Amado, Nuno Alves, Paula Pascoal-Faria; The influence of scaffold design in electrical field distribution for tissue engineering. AIP Conf. Proc. 1 September 2023; 2849 (1): 150001. https://doi.org/10.1063/5.0162362.