Logo do repositório
 
Publicação

Microneedling-enhanced dermal delivery of catechin and curcuminoid polyphenols from gel, patch and ointment formulations

2027-01-01Artigo científico Acesso aberto
Ver registo simples
datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosEngenharia e Tecnologia::Engenharia dos Materiais
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorViolante, Cristiana
dc.contributor.authorMarques-da-Silva, Dorinda
dc.contributor.authorLagoa, Ricardo
dc.date.accessioned2026-10-06T21:49:49Z
dc.date.available2026-10-06T21:49:49Z
dc.date.issued2027-01-01
dc.descriptionArticle number - 108928.
dc.descriptionAcknowledgments and Funding: This work was supported by Fundação para a Ciência e Tecnologia (FCT-Portugal) through the project PTDC/BIA-MIB/31864/2017. The research was also supported by FCT/MCTES through national funds to the research units: LSRE-LCM, UID/50020/2025 (DOI: 10.54499/UID/50020/2025); and ALiCE, LA/P/0045/2020 (DOI: 10.54499/LA/P/0045/2020).
dc.description.abstractPolyphenols exhibit a wide range of biological and pharmacological activities, yet their dermal delivery is often limited by skin permeability and formulation-dependent constraints. In this work, the potential of roller microneedling as a physical strategy to improve dermal delivery of representative polyphenols—epicatechin, epigallocatechin gallate (EGCG), and curcumin—was investigated using common topical dosage forms, namely polymeric gel, patch, and ointment. Standardized skin permeation parameters were first obtained using excised porcine skin under conditions of stratum corneum saturation. The microneedling procedure was characterized, and its effect on polyphenol transdermal permeation from each formulation type was evaluated using Franz diffusion cells. Maximum steady-state permeation fluxes varied from 13.2 μg/cm2/h (curcumin) to 708 μg/cm2/h (epicatechin). Roller microneedling produced well-defined microchannels across the stratum corneum, with a mean interchannel distance of 2.3 mm, without compromising skin integrity, and significantly enhanced polyphenol permeation from all tested vehicles. Depending on the compound and formulation, microneedling increased permeation fluxes and/or reduced lag times, with particularly relevant effects observed for gel-delivered curcumin and ointment-delivered EGCG. Moreover, the polyphenols exhibited a robust antioxidant activity (equivalent to micromolar ascorbic acid) after transdermal permeation, including following microneedle-assisted delivery, supporting the compatibility of microneedling and the formulation vehicles with polyphenol functionality. Overall enhancement factors were consistent, yielding approximately twofold increases in both permeation flux and antioxidant activity. These findings demonstrate that roller microneedling is a practical, low-invasive approach to enhance the dermal delivery of polyphenols from conventional topical formulations, offering a versatile strategy that complements formulation-based optimization for therapeutic and cosmetic applications.eng
dc.description.sponsorshipThis work was supported by Fundação para a Ciência e Tecnologia (FCT-Portugal) through the project PTDC/BIA-MIB/31864/2017. The research was also supported by FCT/MCTES through national funds to the research units: LSRE-LCM, UID/50020/2025 (DOI: 10.54499/UID/50020/2025); and ALiCE, LA/P/0045/2020 (DOI: 10.54499/LA/P/0045/2020).
dc.identifier.citationViolante, C., Marques-da-Silva, D., & Lagoa, R. (2026). Microneedling-enhanced dermal delivery of catechin and curcuminoid polyphenols from gel, patch and ointment formulations. Journal of Drug Delivery Science and Technology, 127, Artigo 108928. https://doi.org/10.1016/j.jddst.2026.108928
dc.identifier.doi10.1016/j.jddst.2026.108928
dc.identifier.issn1773-2247
dc.identifier.urihttp://hdl.handle.net/10400.8/16977
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationALICE - Associate Laboratory in Chemical Engineering
dc.relation.hasversionhttps://doi.org/10.1016/j.jddst.2026.108928
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAlginate
dc.subjectCurcuminoids
dc.subjectDrug delivery
dc.subjectFlavonoids
dc.subjectMedical devices
dc.subjectPluronic F-127
dc.titleMicroneedling-enhanced dermal delivery of catechin and curcuminoid polyphenols from gel, patch and ointment formulationseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPTDC/BIA-MIB/31864/2017
oaire.awardNumberUID/50020/2025
oaire.awardNumberLA/P/0045/2020
oaire.awardTitleMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleALICE - Associate Laboratory in Chemical Engineering
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIB%2F31864%2F2017/PT
oaire.awardURIhttp://hdl.handle.net/10400.8/16870
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0045%2F2020/PT
oaire.citation.endPage14
oaire.citation.startPage1
oaire.citation.titleJournal of Drug Delivery Science and Technology
oaire.citation.volume127
oaire.fundingStream3599-PPCDT
oaire.fundingStreamAvaliação UID 2023/2024
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameViolante
person.familyNameMarques da Silva
person.familyNameLagoa
person.givenNameCristiana
person.givenNameDorinda
person.givenNameRicardo
person.identifier124357
person.identifier.ciencia-id521A-35C1-078D
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0009-0003-6081-0427
person.identifier.orcid0000-0003-0460-5421
person.identifier.orcid0000-0003-2375-6612
person.identifier.scopus-author-id23051352300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication82837f94-5603-49fe-8ebb-67a5ab3398ed
relation.isAuthorOfPublication475787c4-cf46-4b3b-96ec-a5278d5cc6f5
relation.isAuthorOfPublication8a139213-9a89-4bd3-93ee-1e332519f96b
relation.isAuthorOfPublication.latestForDiscovery82837f94-5603-49fe-8ebb-67a5ab3398ed
relation.isProjectOfPublication2097cd8a-31ac-4da8-9326-1493f8925358
relation.isProjectOfPublication5777c7ed-0d7f-46c7-a001-f84c4ce67efb
relation.isProjectOfPublicationf46e7f95-7a64-4461-a140-7ef90ac7b296
relation.isProjectOfPublication.latestForDiscovery2097cd8a-31ac-4da8-9326-1493f8925358

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Microneedling-enhanced dermal delivery of catechin and curcuminoid polyphenols from gel, patch and ointment formulations.pdf
Tamanho:
6.2 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.32 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

LSRE-LCM - Artigos em Revistas Nacionais e de Circulação Internacional
ESTG - Artigos em revistas internacionais